Abstract:
Autoimmune disease is a complex term, which describes immune system attacks as a breakdown of tolerance to auto reactive immune cells. It is associated with genetic, infectious,environmental predisposing factor.The use of herbal medicines in autoimmune significantly act on immune system and improves them. Tetrandrine (Tet), a bis-benzylisoquinoline alkaloid isolated from the creeper Stephania tetrandra S Moore, belong to family Menispermacae has been used for decades in Mainland China to treat patients autoimmune illnesses rheumatism. Punarnavine, alkaloid obtained from Boerhavia diffusa belong to familyNyctaginaceae. Punarnavine significantly reduced the LPS induced elevated levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6 in mice. This review summarizes ADMET Study of tetrandrine and punarnavine by software analysis SWISS ADME and ADME2.0 and determine drug likeliness.(1)
